ABSTRACT
<p><b>OBJECTIVES</b>To investigate the expression and clinical significance of BATF2 in the oral tongue squamous cell carcinoma (OTSCC).</p><p><b>METHODS</b>Expression of BATF2 mRNA and protein in 16 paired OTSCC tissues and adjacent non-tumor mucosa were examined using quantitative PCR, western blotting analysis and immunohistochemistry assays, and the relation between BATF2 expression and clinical pathologic factor and prognosis was analyzed.</p><p><b>RESULTS</b>In 16 paired tissues, expression of BATF2 mRNA in 13 OTSCC tissues and expression of BATF2 protein in 14 OTSCC tissues were significantly lower than that in adjacent non-tumor mucosa. In 202 paraffin-embedded OTSCC samples, BATF2 was not expressed in 20 cases (9.9%), low expressed in 104 cases (51.5%) and highly expressed in 78 (38.6%). BATF2 expression level was significantly correlated with histological differentiation (P = 0.002). Patients with low BATF2 expression had significantly poorer overall survival and disease-free survival than those with high BATF2 expression (P < 0.001).</p><p><b>CONCLUSIONS</b>BATF2 was low expressed in OTSCC and related to tumor differentiation and prognosis and may serve as a prognostic biomarker and potential therapeutic target for this disease.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Basic-Leucine Zipper Transcription Factors , Genetics , Metabolism , Blotting, Western , Carcinoma, Squamous Cell , Metabolism , Pathology , Immunohistochemistry , Mouth Mucosa , Metabolism , Prognosis , RNA, Messenger , Metabolism , Tongue Neoplasms , Metabolism , PathologyABSTRACT
Livin is a new and important member of the inhibitor of apoptosis protein(IAPs)family.Livin is high expressed in most human tumor cells, involved in apoptosis inhibition and closely related with tumor development and progression.Studies found that through the down-regulation or inhibition of Livin expression and the induction specific antibodies of Livin could inhibi and kill tumor cells, which provided a new method for tumors'diagnosis, cell and gene targeted therapy.
ABSTRACT
To introduce the method, content and the benefit of constituting inspection tour quality bulletin system and as- sessing the inspection tour computer capability grade of the quarter inspection tour of computer repair and maintenance outsourcing service. By improving the computer routine inspection tour in practice, we can enhance the integrated benefit of the computer quarter inspection tour. As an effective approach of the network equipment preventive repair and mainte- nance, after the computer quarter inspection tour system was optimized and improved, it got the end-users and hospital or- ganization' high attention and full affirmation for the good integrated benefit.